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Home » Products » Active Pharmaceutical Ingredients » CHLORPHENIRAMINE MALEATE

CHLORPHENIRAMINE MALEATE

CHLORPHENIRAMINE MALEATE
CHLORPHENIRAMINE MALEATE
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Product Code : JSR-23
Product Description

NAME :- CHLORPHENIRAMINE MALEATE

IUPAC NAME :- (Z)-but-2-enedioic acid; 3-(4-chlorophenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amine

CAS NO. :- 113-92-8

FORMULA :- C20H23ClN2O4

SYNONYMS :- alunex;piriex;Haynon;c-meton;ibioton;lorphen;piriton;teldrin;Puermin;allergin

APPLICATION :- An antagonist of the histamine H1-receptor

DESCRIPTION :- Chlorpheniramine Maleate is a small molecule H1-receptor antagonist. Increased ornithine decarboxylase activity induced in an ischemia-reperfusion state was attenuated by Chlorpheniramine Maleate, indicating that this increase is mediated through engagement of the H1-receptor by histamine. Histamine-mediated repair of intestinal mucosa following ischemia-reperfusion was also demonstrated to operate through the H1-receptor with Chlorpheniramine Maleate. Induction of ornithine decarboxylase was blocked by Chlorpheniramine Maleate in Ehrlich carcinoma and MCF-7 cells. The positive inotropic effect of H1-receptor stimulation by histamine on protein tyrosine phosphorylation in guinea pig left atrium was antagonized by Chlorpheniramine Maleate.



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