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NIFEDIPINE

NIFEDIPINE
NIFEDIPINE
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Product Code : JRS-181
Product Description

NAME :- NIFEDIPINE

IUPAC NAME :- 3,5-dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

CAS NO. :- 21829-25-4

FORMULA :- C17H18N2O6

SYNONYMS :- Orix;Oxcord;ADALAT;Anifed;bay1040;Nifedin;Nifelan;Pidilat;Sepamit;Zenusin

APPLICATION :- For the management of vasospastic angina, chronic stable angina, hypertension, and Raynaud's phenomenon. May be used as a first line agent for left ventricular hypertrophy and isolated systolic hypertension (long-acting agents).

DESCRIPTION :- Nifedipine has been formulated as both a long- and short-acting 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, nifedipine prevents calcium-dependent myocyte contraction and vasoconstriction. A second proposed mechanism for the drug’s vasodilatory effects involves pH-dependent inhibition of calcium influx via inhibition of smooth muscle carbonic anhydrase. Nifedipine is used to treat hypertension and chronic stable angina.



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