ALENDRONATE SODIUM TRIHYDRATE

Product Description

Alendronate Sodium

Alendronate Sodiumis a second-generation bisphosphonate that contains nitrogen. Bisphosphonate was first used in the treatment of Paget s disease in 1971. This class of medication comprises inorganic pyrophosphate analogues containing non-hydrolyzable P-C-P bonds. Just like other bisphosphonates, chemical compound has a high affinity for bone mineral and is taken up during osteoclast resorption. Alendronate slows down farnesyl pyrophosphate synthetase. It is an enzymein the mevalonic acid pathway involved in the production of isoprenoid compounds, essential for post-translational modification of small guanosine triphosphate (GTP)-binding proteins, like Rho, Ras and Rab. Inhibition of this process interferes with function and survival of osteoclast. Alendronate is used to treat osteoporosis and Paget s disease. 

NAME :- ALENDRONATE SODIUM

IUPAC NAME :- sodium [4-amino-1-hydroxy-1-(hydroxy-oxido-phosphoryl)- butyl]phosphonic acid trihydrate

CAS NO. :- 121268-17-5

FORMULA :- C₄H₁₃NO₇P₂

SYNONYMS :- G-704650;ALENDRONATE SODIUM SALT;ALENDRONATE, SODIUM SALT TRIHYDRATE;ALENDRONATE SODIUM TRIHYDRATE;ALENDRONNATE SODIUM TRIHYDRATE;ALENDRONIC ACID, MONOSODIUM SALT, TRIHYDRATE;ADRONAT;4-AMINO-1-HYDROXYBUTYLIDINE-1,1-BISPHOSPHONATE SODIUM SALT TRIHYDRATE

APPLICATION :- Inhibits bone resorption and increases bone density.

DESCRIPTION :- Alendronate chemical compound is a nitrogen-containing, second generation bisphosphonate. Bisphosphonates were first used to treat Paget s disease in 1971. This class of medications is comprised of inorganic pyrophosphate analogues that contain non-hydrolyzable P-C-P bonds. Similar to other bisphosphonates, alendronate has a high affinity for bone mineral and is taken up during osteoclast resorption. Alendronate inhibits farnesyl pyrophosphate synthetase, one of the enzymes in the mevalonic acid pathway involved in producing isoprenoid compounds that are essential for post-translational modification of small guanosine triphosphate (GTP)-binding proteins, such as Rho, Ras and Rab. Inhibition of this process interferes with osteoclast function and survival. Alendronate is used for the treatment of osteoporosis and Paget s disease.

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