NAME LOSARTAN POTASSIUM
IUPAC NAME 2butyl4chloro1422H1234tetrazol5ylphenylphenylmethyl1Himidazol5ylmethanol
CAS NO 124750998
FORMULA C22H22CIN6OK
SYNONYMS potassium2butyl5chloro342123triaza4azanidacyclopenta25dien5ylphenylphenylmethylimidazol4ylmethanol
APPLICATION Antihypertensive
DESCRIPTION Losartan Potassium is a specific antagonist of the angiotensin II receptor subtype AT1 Antagonism of the AT1 receptor and interference of association between AT1 and angiotensin II produces vasodilation and reduction of hypertension This antagonism has other downstream effects including a correlated antagonism of the thromboxane A2 receptor inhibition of platelet aggregation and induction of peroxisome proliferatoractived receptor gamma PPAR activity