NAME :- MEPYRAMINE MALEATE
IUPAC NAME :- (Z)-but-2-enedioic acid; N-[(4-methoxyphenyl)methyl]-N',N'-dimethyl-N-pyridin-2-ylethane-1,2-diamine
CAS NO. :- 59-33-6
FORMULA :- C21H27N3O5
SYNONYMS :- Mepyramine maleate;Pyrilamine Maleate;N-(4-methoxybenzyl)-N',N'-dimethyl-N-(pyridin-2-yl)ethane-1,2-diamine;N-(4-methoxybenzyl)-N',N'-dimethyl-N-pyridin-2-ylethane-1,2-diamine (2Z)-but-2-enedioate;N-(4-methoxybenzyl)-N',N'-dimethyl-N-pyridin-2-ylethane-1,2-diamine (2E)-but-2-enedioate;
APPLICATION :- A histamine H1 receptor antagonist
DESCRIPTION :- Mepyramine is a histamine H1 receptor antagonist and binds with high affinity to G(q/11) protein. Mepyramine maleate is found to be a potent inhibitor of CYP2D6 (P450 2D forms) in hepatocytes, and PAF-induced platelet aggregation. Mepyramine is commonly utilized as a radioligand ([3H]Mepyramine) binding assay for the H1 receptor. This product has been recently discovered to exhibit blocking ability of KCNQ/M channels which is potentially related to an adverse effect seen in excess intake of antihistamines.