NAME :- MINOXIDIL
IUPAC NAME :- 6-Piperidin-1-ylpyrimidine-2,4-diamine 3-oxide
CAS NO. :- 38304-91-5
FORMULA :- C9H15N5O
SYNONYMS :- pdp;regain;lonolox;alostil;regaine;rogaine;U-10858;loniten;alopexil;prexidil
APPLICATION :- A selective ATP dependent K+ (Kir6) channel activator
DESCRIPTION :- Minoxidil (U-10858) is a selective ATP dependent K+ channel (Kir6) activator. As a result membrane permeability increases the flow of K+ across the membrane, which turns off voltage gated calcium channels. This inhibition in action potential causes a relaxation in arteriolar smooth muscle. Alternate studies indicate that Minoxidil (U-10858) activates the Î²-catenin pathway in human dermal papilla cells which results in accumulation of Î²-catenin in the nucleus.