NAME :- MONTELUKAST SODIUM
IUPAC NAME :- sodium 2-1-(1R)-1-3-(E)-2-(7-chloroquinolin-2-yl)ethenyl phenyl-3- 2-(2-hydroxypropan-2-yl)phenyl]propyl sulfanylmethyl cyclopropyl acetate
CAS NO. :- 151767-02-1
FORMULA :- C35H35CINO3S.NA
SYNONYMS :- mk-476;MK-476-d6;singulair;MONTELUKAST NA;MK-476, Singulair;Motelukast SodiuM;MONTELUKST SODIUM;MONTELUKAST SODIUM;Montelukast SoudiuM;Montelukast SodiuM USP
APPLICATION :- A potent and highly selective CysLT1 receptor antagonist, without demonstrated CysLT2 activity
DESCRIPTION :- Montelukast Sodium is a potent, selective, anti-inflammatory CysLT1 receptor antagonist (IC50 < 5nM) with no appreciable affect on the CysLT2 receptor. In rat colitis Montelukast Sodium has demonstrated the ability to increase PGE2 (Prostaglandin E2 - sc-201225) production . Inhibition is competitive with respect to leukotrienes - particularly LTD4, a biologically active mediator that plays an important role in the control of several biochemical pathways involving pulmonary and immune system function.
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