NAME :- PAMIDRONATE SODIUM
IUPAC NAME :- disodium [3-amino-1-hydroxy-1-[hydroxy(oxido)phosphoryl]propyl]-hydroxyphosphinate
CAS NO. :- 57248-88-1
FORMULA :- C3H9NNA2O7P2
SYNONYMS :- ;pamidronate disodium;disodium (3-amino-1-hydroxypropane-1,1-diyl)bis[hydrogen (phosphonate)];pamidronate disodium salt;3-amino-1-hydroxy-1-phosphonopropyl phosphonic acid disodium salt;phosphonate, P,P'-(3-amino-1-hydroxypropylidene)bis-, sodium salt (1:2);
APPLICATION :- A farnesyl diphosphate synthase inhibitor
DESCRIPTION :- Pamidronate disodium salt is a bisphosphonate compound, which inhibits farnesyl diphosphate synthase and bone resorption. Studies suggest that Pamidronate disodium salt stimulates polymorphonuclear leukocyte and platelet derived nitric oxide production. It is believed that this nitric oxide production can lead to a negative feedback mechanism, which could restrict the inflammatory process and reduce bone resorption. Furthermore, bisphosphonates induce endothelial cell death, cancer cell apoptosis, and nuclear factor-κB pathway activation, via the endothelial protein C receptor.