NAME :- ZONISAMIDE
IUPAC NAME :- benzo[d]isoxazol-3-ylmethanesulfonamide
CAS NO. :- 68291-97-4
FORMULA :- C8H8N2O3S
SYNONYMS :- ZON;ci-912;ad-810;pd110843;excegram;exceglan;Excegran; Zonegran;Excemide;ZONISAMIDE
APPLICATION :- For use as adjunctive treatment of partial seizures in adults with epilepsy.
DESCRIPTION :- Zonisamide is a sulfonamide anticonvulsant approved for use as an adjunctive therapy in adults with partial-onset seizures. Zonisamide may be a carbonic anhydrase inhibitor although this is not one of the primary mechanisms of action. Zonisamide may act by blocking repetitive firing of voltage-gated sodium channels leading to a reduction of T-type calcium channel currents, or by binding allosterically to GABA receptors. This latter action may inhibit the uptake of the inhibitory neurotransmitter GABA while enhancing the uptake of the excitatory neurotransmitter glutamate.