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Pharmaceutical Pellets

In pharmaceutical sector, Pharmaceutical Pellets are the multiparticulate dosage varieties, which were made via the accumulation of drugs as well as fine powdered excipients collectively. The blend leads to the placement of little free flowing semi spherical as well as fully spherical particles. These can be characterized as the free-flowing, small and spherical particulates produced via the accumulation of granules, fine powders of drug kernels and excipients by making the use of befitting processing equipment. These are of primal interest over several kindred techniques on account of their uniformity of dose, less friability and little susceptibility of dose dumping etc. With the arrival of controlled release technology, Pharmaceutical Pellets are widely comprehended for their control release property in gastrointestinal area.

Key Points:

1) Modify the aesthetic appearance of products.
2) Assist in attaining controlled release rate of medicates.
3) Enable finer distribution, absorption and dissolution.
4) Inure better flow properties as well as flexibility in manufacture & formulation development.
Esomeprazole Magnesium Pellets
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Esomeprazole Magnesium Pellets
JRS-785
The IUPAC name of Esomeprazole Magnesium Pellets is magnesium; 5-methoxy-2-[(4-methoxy-3,5-dimethylpyridin-2-yl) methylsulfinyl] benzimidazol-1-ide; 5-methoxy-2-[(4-methoxy-3,5-dimethylpyridin-2-yl) methylsulfinyl] benzimidazol-1-ide. They have the chemical formula C34H42MgN6O9S2 and the molar mass is 767.168 g/mol. These are the magnesium salt of esomeprazole and has the property of gastric proton pump inhibition. They perform their function by developing one or more covalent disulfide bonds with proton pump thereby restricting its activity and there is no secretion of H+ ions into the gastric lumen.
Itraconazole Pellets
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Itraconazole Pellets
JRS-766
Itraconazole Pellets have the chemical formula C35H38CI2N8O4 and its IUPAC name is 2-butan-2-yl-4-[4-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl] methoxy] phenyl] piperazin-1-yl]phenyl]-1,2,4-triazol-3-one. They act as antifungal agent and are widely used in the treatment of upset stomach, indigestion, and various gastrointestinal conditions. They act by inhibiting the fungal cytochrome P450 oxidase which mediates the synthesis of ergosterol. These drugs are also prescribed to those patients who have systemic infections such as aspergillosis, candidiasis, and cryptococcosis.
Lansoprazole Pellets
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Lansoprazole Pellets
JRS-465
Lansoprazole Pellets are recognized by several other brand names including Lansoprazole, Prevacid, Monolitum, Bamalite, Takepron, Agopton, Ogastro, Lanzor, and Opiren. Their chemical formula is C16H14F3N3O2S and the IUPAC name is 2-[[3-methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl]methylsulfinyl]-1H-benzimidazole. They are commonly used in the treatment of gastroesophageal reflux disease (GERD), erosive esophagitis, duodenal ulcers, Helicobacter pylori infections, and stomach ulcer. These pellets act as proton pump inhibitor and are blockbuster molecules that are used in the treatment of ulcer.
Omeprazole Pellets
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Omeprazole Pellets
JRS-E78
The chemical formula of Omeprazole Pellets is C17H19N3O3S and the IUPAC name is 6-methoxy-2-[(4-methoxy-3,5-dimethylpyridin-2-yl) methylsulfinyl]-1H-benzimidazole. These pellets are used in used in the treatment of Gastroesophageal reflux disease (GERD) in which there is a backward flow of acid from the stomach causing heartburn and injury to the food pipe (esophagus). They are available in the market in white or off-white spherical pellets. These drugs act as anti-ulcerant and are widely utilized in the treatment of peptic ulcers.
Pantoprazole Sodium Pellets
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Pantoprazole Sodium Pellets
JRS-E67
Pantoprazole Sodium Pellets are available as white-colored pellets and mainly used in the treatment of peptic ulcers. Their chemical formula is C16H14F2N3NaO4S and the IUPAC name is sodium 5-(difluoromethoxy)-2-[(3,4-dimethoxypyridin-2-yl) methylsulfinyl] benzimidazol-1-ide. These pellets are prepared by fluid bed coating technology in which there is a direct compression of the enteric-coated pellets and suitable excipients. They are sold by different brand names such as Somac, Pantoloc, Protium, Pantecta, Protonix, and Pantohea.