NAME :- DAUNORUBICIN HCL
IUPAC NAME :- (7S,9S)-9-acetyl-7-[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione
CAS NO. :- 20830-81-3
FORMULA :- C27H30ClNO10
SYNONYMS :- ondena;Cerubidine;ndc0082-4155;daunoblastin;daunoblastina;DAUNOBLASTINE;DAUNOMYCIN HCL;DAUNOMYCINE HCL;DAUNORUBICIN HCL;WP900 HYDROCHLORIDE
APPLICATION : Oncology
DESCRIPTION :- Daunorubicin hydrochloride is a DNA intercalating anthracylcine natural product isolated from Streptomyces peucetius. Upon intercalation, Daunorubicin forms stable complexes with the DNA backbone, inhibiting normal functioning of the double helix and the proteins that interact with it. Daunorubicin is nearly identical in structure to Doxorubicin (sc-200923), with Doxorubicin containing a pendant hydroxyl group on the exocyclic ketone. The action of Daunorubicin has been correlated to efficacy in suppressing the proliferation of certain acute leukemias. Daunorubicin hydrochloride is an inhibitor of Topo I and Topo II and an activator of LASS.