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Glibenclamide Powder

Glibenclamide Powder

3000 INR/Kilograms

Product Details:

  • Medicine Name Glibenclamide
  • Grade Industrial Grade
  • Physical Form Powder
  • Supply Ability : 500 Kilograms Per Day
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Price And Quantity

  • 10 Kilograms
  • 3000 INR/Kilograms

Product Specifications

  • Powder
  • Glibenclamide
  • Industrial Grade

Trade Information

  • 500 Kilograms Per Day
  • 1 Days

Product Description

NAME :- GLIBENCLAMIDE


IUPAC NAME :- 5-chloro-N-(4-[N-(cyclohexylcarbamoyl)sulfamoyl]phenethyl)-2-methoxybenzamide


CAS NO. :- 10238-21-8


FORMULA :- C23H28CIN3O5S


SYNONYMS :- 5-Chloro-N-[4-(cyclohexylureidosulfonyl)phenethyl]-2-methoxybenzamide; N-p-[2-(5-Chloro-2-methoxybenzamido)ethyl]benzenesulfonyl-N-cyclohexylurea


APPLICATION :- Antidiabetic


DESCRIPTION :- Glyburide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating  cells of the pancreas to release insulin. Sulfonylureas increase both basal insulin secretion and meal-stimulated insulin release. Medications in this class differ in their dose, rate of absorption, duration of action, route of elimination and binding site on their target pancreatic  cell receptor. Sulfonylureas also increase peripheral glucose utilization, decrease hepatic gluconeogenesis and may increase the number and sensitivity of insulin receptors. Sulfonylureas are associated with weight gain, though less so than insulin. Due to their mechanism of action, sulfonylureas may cause hypoglycemia and require consistent food intake to decrease this risk. The risk of hypoglycemia is increased in elderly, debilitated and malnourished individuals. Glyburide has been shown to decrease fasting plasma glucose, postprandial blood glucose and glycosolated hemoglobin (HbA1c) levels (reflective of the last 8-10 weeks of glucose control). Glyburide appears to be completely metabolized, likely in the liver. Although its metabolites exert a small hypoglycemic effect, their contribution to glyburides hypoglycemic effect is thought to be clinically unimportant. Glyburide metabolites are excreted in urine and feces in approximately equal proportions. The half-life of glyburide appears to be unaffected in those with a creatinine clearance of greater than 29 ml/min/1.73m2.

Product details 

Application

Antidiabetic

Molecular Formula

C23H28CIN3O5S

IUPAC Name

5-chloro-N-(4-[N-(cyclohexylcarbamoyl)sulfamoyl]phenethyl)-2-methoxybenzamide

CAS Number

10238-21-8

 

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